Progression Risk Stratification of Asymptomatic Waldenström Macroglobulinemia
نویسندگان
چکیده
منابع مشابه
Risk of second cancers in Waldenström macroglobulinemia.
BACKGROUND An increased incidence of second cancers has been reported in lymphoproliferative disorders. PATIENTS AND METHODS We assessed the frequency, characteristics and predictive factors of second cancers in 230 patients with Waldenström macroglobulinemia (WM) and compared the incidence of second cancers in WM with that of an age- and sex-matched control population. RESULTS Twenty-two p...
متن کاملWaldenström macroglobulinemia.
Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma. A serum monoclonal IgM protein is required to establish this diagnosis. The clinical features patients develop include normochromic normocytic anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy and signs of hyperviscosity. The International Staging System for Waldenström macroglobulinemia divides patients prognostically ...
متن کاملExtramedullary Waldenström macroglobulinemia.
Disease assessment in Waldenstrom Macroglobulinemia (WM) is dependent on the percent involvement of B-cell neoplasm in the bone marrow and IgM paraprotein in the serum. A subset of patients also demonstrates extramedullary involvement, which is infrequently examined. The role of extramedullary involvement in the diagnosis and prognosis of WM is poorly understood. The purpose of this study is to...
متن کاملBiology, prognosis, and therapy of Waldenström Macroglobulinemia.
Waldenström Macroglobulinemia (WM) is a rare B-cell lymphoma characterized by the uncontrolled accumulation of malignant lymphoplasmacytic cells, mainly in the bone marrow, and monoclonal IgM production. Despite its rarity, our understanding of the biology of this disease has improved significantly in recent years with the identification of recurrent mutations in the MYD88 and CXCR4 genes. Base...
متن کاملImmunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.
We retrospectively reviewed the immunophenotypic profile of 75 cases of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) analyzed by flow cytometry. All patients had monoclonal IgM (median, 2,100 mg/dL [21 g/L]) in serum and were considered clinically to have WM. The neoplastic cells, in all cases, expressed monoclonal immunoglobulin light chain (k, 55; l, 20) and CD19, and eve...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2019
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.19.00394